Estradiol

ChemistryAlso known as: 17β-EstradiolAlso known as: E2pg/mL

Measures estradiol hormone levels in saliva.

Normal Range
0.1 – 1.5 pg/mL
pg/mL
Abnormal Levels
Consult your provider
Specimen Type
Blood

Why This Biomarker Matters

Estradiol balance is crucial for bone health, mood, sexual function, and cardiovascular health. Salivary testing provides insight into active hormone levels and helps optimize hormone therapy or identify imbalances.

Understanding Your Results

Normal Range

0.1 – 1.5 pg/mL

Overview

Estradiol is the primary estrogen hormone in the body, measured through saliva. Salivary estradiol reflects biologically active hormone levels and is useful for tracking hormonal changes throughout the menstrual cycle, during perimenopause, or with hormone therapy. Abnormal estradiol levels can affect mood, bone health, sexual function, and cardiovascular risk. This non-invasive test helps assess hormone balance and guide treatment decisions.

Related Health Conditions

Conditions where Estradiol is commonly tested

Female infertility

Hypogonadism

Male infertility

Menopause

Related Health Goals

Balance Hormones

Support Reproductive Health

Treatments & Interventions

Therapies monitored using Estradiol

Progesterone

Testosterone

Bromocriptine mesylate

Estrone

Human chorionic gonadotropin

Estrogen receptor agonist-containing product

Testosterone propionate

Estradiol benzoate

Estradiol valerate

Estradiol cypionate

Testosterone cypionate

Estradiol hemihydrate

Testosterone enanthate

Polyestradiol phosphate

Ethinylestradiol

Clinical Trials

59
Total Trials
7
Recruiting
17
With Results

Recent Trials

Adaptions and Resiliency to Multi-Stressor OpeRations

NCT06455969Phase 4Recruiting120 enrolled

52 Week Study + 24-Month Long-Term Extension of Safety, PK, & Efficacy of XYOSTED® for Testosterone Replacement in Male Adolescents With Hypogonadism

NCT06689085Phase 3Recruiting100 enrolled

Determining Dose Equivalence Between Oral and Transdermal Estrogen Treatment in Women With Turner Syndrome

NCT06544473Phase 4Recruiting50 enrolled

Long Term Effects of Oral Versus Transdermal Estrogen Replacement Therapy in Turner Syndrome

NCT06570460Phase 4Recruiting50 enrolled

A Phase 4 Study to Evaluate Adrenal Function in Hypogonadal Men Treated With JATENZO® for 12 Months

NCT06385509Phase 4Active Not Recruiting110 enrolled
View all 59 trials on ClinicalTrials.gov

Technical Information (LOINC Codes)

Standardized laboratory codes for this biomarker

2243-4Primary
Estradiol (E2) [Mass/volume] in Serum or Plasma
pg/mL
35384-7
Estradiol (E2) [Mass/volume] in Serum or Plasma by High sensitivity method
pg/mL
2238-4
Estradiol (E2) [Mass/volume] in Saliva (oral fluid)
pg/mL
14715-7
Estradiol (E2) [Moles/volume] in Serum or Plasma
pmol/L
83096-8
Estradiol (E2) [Mass/volume] in Serum or Plasma by Immunoassay
pg/mL
31176-1
Estradiol (E2) [Mass/volume] in Amniotic fluid
pg/mL
34286-5
Estradiol (E2) [Moles/volume] in Urine
pmol/L
34287-3
Estradiol (E2) [Moles/volume] in 24 hour Urine
pmol/L
55857-7
Estradiol (E2) [Mass/volume] in Body fluid
pg/mL
55858-5
Estradiol (E2) [Moles/volume] in Body fluid
pmol/L
72873-3
Estradiol (E2) [Moles/volume] in Serum or Plasma by High sensitivity method
pmol/L
83097-6
Estradiol (E2) [Moles/volume] in Serum or Plasma by Immunoassay
pmol/L
97741-3
Estradiol (E2) [Moles/volume] in Aspirate
nmol/L
12595-5
Estradiol (E2) [Mass/volume] in Urine
pg/mL
97742-1
Estradiol (E2) [Mass/volume] in Aspirate
pg/mL
21263-9
Estradiol (E2) [Mass/time] in 24 hour Urine
ng/(24.h)
2239-2
Estradiol (E2) [Mass/volume] in Semen
pg/mL
2245-9
Estradiol (E2) [Moles/mass] in Tissue
umol/g
25401-1
Estradiol (E2) [Moles/time] in 24 hour Urine
nmol/(24.h)

Available Lab Tests

Order tests that measure this biomarker

Estradiol Test

$24.64

Estradiol, Ultrasensitive (LC/MS/MS)

$31.85
Results in 3-5 business days

Find Specialists

Doctors who commonly order this test

Endocrinology, Diabetes & Metabolism
Obstetrics & Gynecology
Reproductive Endocrinology
Urology