Substance / Medication

Amiloride

Overview

Active Ingredient
amiloride
RxNorm CUI
644

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Clinical Trials

11 trials linked to this intervention

11
Total Trials
1
Recruiting
1
With Results

Research Evidence

Published studies and systematic reviews

Sort:
In resistant hypertension, amiloride was noninferior to spironolactone for reducing home SBP at 12 wk.
Romiti Giulio Francesco, Bonini Niccolò, [object Object] · Ann Intern Med · 2025
PMID: 40889369RCT
Amiloride versus furosemide for the treatment of edema in patients with nephrotic syndrome: A pilot study (AMILOR).
Schork Anja, Vogel Elisabeth, Bohnert Bernhard N et al. · Acta Physiol (Oxf) · 2024
PMID: 38822593RCT
A 10-mg dose of amiloride increases time to failure during blood-flow-restricted plantar flexion in healthy adults without influencing blood pressure.
Stavres Jon, Luck J Carter, Hamaoka Takuto et al. · Am J Physiol Regul Integr Comp Physiol · 2022
PMID: 36222880RCTFull text (PMC)
The Effect of Amiloride on Proteinuria in Patients with Proteinuric Kidney Disease.
Shen Wen, Alshehri Mohammed, Desale Sameer et al. · Am J Nephrol · 2021
PMID: 33957621RCT
Effectiveness of chlorthalidone/amiloride versus losartan in patients with stage I hypertension: results from the PREVER-treatment randomized trial.
Fuchs Flávio D, Scala Luiz César N, Vilela-Martin José F et al. · J Hypertens · 2016
PMID: 26938814RCT

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Amiloride (substance)
SNOMED CT
387503008
UMLS CUI
C0002502
RxNorm CUI
644

Clinical Data

This intervention maps to 16 entities in the Healos knowledge graph.

6
Conditions
5
Biomarkers
3
Specialists
0
Symptoms
11
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.