Substance / Medication

Cimicifuga racemosa extract

Overview

Active Ingredient
black cohosh extract
RxNorm CUI
236665

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Clinical Trials

72 trials linked to this intervention

72
Total Trials
12
Recruiting
22
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Cimicifuga racemosa extract for relieving menopausal symptoms: a randomized controlled trial.
Tanmahasamut P, Vichinsartvichai P, Rattanachaiyanont M et al. · Climacteric · 2015
PMID: 24941138RCT
No effect of Cimicifuga racemosa extract on serum interleukin-6 levels and prostacyclin production by human endothelial cells.
Pineda Begoña, García-Pérez Miguel Angel, Vázquez Francisco et al. · Eur J Obstet Gynecol Reprod Biol · 2009
PMID: 19233537RCT
The effect of a Cimicifuga racemosa extracts Ze 450 in the treatment of climacteric complaints--an observational study.
Drewe Juergen, Zimmermann Christian, Zahner Catherine · Phytomedicine · 2013
PMID: 23537746Observational
Evaluation of cell death caused by triterpene glycosides and phenolic substances from Cimicifuga racemosa extract in human MCF-7 breast cancer cells.
Hostanska Katarina, Nisslein Thomas, Freudenstein Johannes et al. · Biol Pharm Bull · 2004
PMID: 15577215Observational
Metabolic switch induced by Cimicifuga racemosa extract prevents mitochondrial damage and oxidative cell death.
Rabenau Malena, Unger Matthias, Drewe Jürgen et al. · Phytomedicine · 2019
PMID: 30599889Other
Attenuation of nucleoside and anti-cancer nucleoside analog drug uptake in prostate cancer cells by Cimicifuga racemosa extract BNO-1055.
Dueregger Andrea, Guggenberger Fabian, Barthelmes Jan et al. · Phytomedicine · 2013
PMID: 23972793Other
Cimicifuga racemosa extract Ze 450 shifts macrophage immunometabolism and attenuates pro-inflammatory signaling.
Günther Madeline, Paczia Nicole, Michels Susanne et al. · Biomed Pharmacother · 2025
PMID: 40382826Preclinical
In Vitro and In Situ Characterization of Triterpene Glycosides From Cimicifuga racemosa Extract.
Disch Lucia, Forsch Kristina, Siewert Beate et al. · J Pharm Sci · 2017
PMID: 28827038Preclinical
Antidiabetic effects of the Cimicifuga racemosa extract Ze 450 in vitro and in vivo in ob/ob mice.
Moser C, Vickers S P, Brammer R et al. · Phytomedicine · 2014
PMID: 25022210Preclinical

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Cimicifuga racemosa extract (substance)
SNOMED CT
412588001
UMLS CUI
C0771967
RxNorm CUI
236665

Clinical Data

This intervention maps to 10 entities in the Healos knowledge graph.

4
Conditions
3
Biomarkers
2
Specialists
0
Symptoms
72
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.