Substance / Medication

Clomiphene citrate

Overview

Clinical overview including description, indications, and evidence base is pending physician authorship or FDA SPL integration. Graph-derived relationship data is available below.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Clinical Trials

9 trials linked to this intervention

9
Total Trials
1
Recruiting
1
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Clomiphene or enclomiphene citrate for the treatment of male hypogonadism: a systematic review and meta-analysis of randomized controlled trials.
Hohl Alexandre, Chavez Matheus Pedrotti, Pasqualotto Eric et al. · Arch Endocrinol Metab · 2025
PMID: 41066380Meta-AnalysisFull text (PMC)
Comparison of Letrozole and Clomiphene Citrate in Pregnancy Outcomes in Patients with Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis.
Abu-Zaid Ahmed, Gari Abdulrahim, Sabban Hussein et al. · Reprod Sci · 2024
PMID: 38030814Meta-Analysis
Letrozole Compared With Clomiphene Citrate for Polycystic Ovarian Syndrome: A Systematic Review and Meta-analysis.
Liu Zhuo, Geng Yuli, Huang Yanjing et al. · Obstet Gynecol · 2023
PMID: 36735392Meta-Analysis
Clomiphene citrate for male infertility: A systematic review and meta-analysis.
Huijben Manou, Huijsmans Roel L N, Lock M Tycho W T et al. · Andrology · 2023
PMID: 36680549Meta-Analysis
Therapeutic efficacy of clomiphene citrate combined with metformin in patients with polycystic ovary syndrome.
Lin Wenxun, Feng Jun, Zhou Honggui et al. · J Clin Pharm Ther · 2022
PMID: 34743357Meta-Analysis
Clomiphene citrate for men with hypogonadism: a systematic review and meta-analysis.
Huijben Manou, Lock M Tycho W T, de Kemp Vincent F et al. · Andrology · 2022
PMID: 34933414Meta-Analysis
A paradoxical decline in semen parameters in men treated with clomiphene citrate: A systematic review.
Gundewar Tejas, Kuchakulla Manish, Ramasamy Ranjith · Andrologia · 2021
PMID: 33108678Meta-Analysis
Higher ovulation rate with letrozole as compared with clomiphene citrate in infertile women with polycystic ovary syndrome: a systematic review and meta-analysis.
Tsiami Alexandra P, Goulis Dimitrios G, Sotiriadis Alexandros I et al. · Hormones (Athens) · 2021
PMID: 34033068Meta-Analysis

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Clomifene citrate (substance)
SNOMED CT
387346007
UMLS CUI
C0546859

Clinical Data

This intervention maps to 9 entities in the Healos knowledge graph.

2
Conditions
3
Biomarkers
3
Specialists
0
Symptoms
9
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.