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Substance / Medication

Conjugated estrogen

SNOMED 126098001UMLS C0014938

Overview

Active Ingredient
estrogens, conjugated (USP)
RxNorm CUI
4099

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Hypogonadism
Primary ovarian failure
Neoplasm of prostate
Neoplasm of breast
Menopausal flushing
Premature ovarian failure
Climacteric flushing

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Thyrotropin

LOINC 3016-3

secondary

Estradiol

LOINC 2243-4

primary

Testosterone

LOINC 2986-8

primary

Clinical Trials

78 trials linked to this intervention

78
Total Trials
14
Recruiting
23
With Results

Recent Trials

TRADE-Testosterone Replacement and Dutasteride Effectiveness

NCT00194675Phase 4Completed53 enrolled

Study Evaluating Totelle® in Menopausal Symptoms and Sexual Function

NCT00195520Phase 4Completed100 enrolled

Efficacy and Safety Study in Postmenopausal Women to Determine the Lowest Effective Dose for Relief of Moderate to Severe Hot-Flushes

NCT00206622Phase 4Completed425 enrolled

Study of Paxil Use in Menopausal Women

NCT00225914Phase 4Completed64 enrolled

Estrogen for Treating Depression in Menopausal Women With Hot Flashes and Insomnia

NCT00227942Phase 4Completed86 enrolled
View all 78 trials on ClinicalTrials.gov

Research Evidence

Published studies and systematic reviews

Sort:
Bazedoxifene plus conjugated estrogens improve menopausal symptoms in postmenopausal women: a systematic review and meta-analysis.
Bi Beilei, Jiang Yi, Shi Yin et al. · Gynecol Endocrinol · 2022
PMID: 36036169Meta-Analysis
Cardiovascular safety of conjugated estrogens plus bazedoxifene: meta-analysis of the SMART trials.
Komm B S, Thompson J R, Mirkin S · Climacteric · 2015
PMID: 25511453Meta-Analysis
Bazedoxifene plus conjugated estrogen to treat menopausal depression-A pilot study.
Kulkarni Jayashri, Mu Eveline, Li Qi et al. · J Pharmacol Exp Ther · 2025
PMID: 40139074RCT
Effects of Raloxifene Combined with Low-dose Conjugated Estrogen on the Endometrium in Menopausal Women at High Risk for Breast Cancer.
Carneiro Andrea Lucia Bastos, Spadella Ana Paula Curi, Souza Fabiola Amaral de et al. · Clinics (Sao Paulo) · 2021
PMID: 33503193RCTFull text (PMC)
Effects of vaginal administration of conjugated estrogens tablet on sexual function in postmenopausal women with sexual dysfunction: a double-blind, randomized, placebo-controlled trial.
Bumphenkiatikul Thanapob, Panyakhamlerd Krasean, Chatsuwan Thanittha et al. · BMC Womens Health · 2020
PMID: 32787848RCTFull text (PMC)
Effect of conjugated estrogens and bazedoxifene on glucose, energy and lipid metabolism in obese postmenopausal women.
Marlatt Kara L, Lovre Dragana, Beyl Robbie A et al. · Eur J Endocrinol · 2020
PMID: 32698159RCTFull text (PMC)
Treatment of Secondary Vestibulodynia with Conjugated Estrogen Cream: A Pilot, Double-Blind, Randomized Placebo-Controlled Trial.
Langlais Eve-Lyne, Lefebvre Jessica, Maheux-Lacroix Sarah et al. · J Obstet Gynaecol Can · 2017
PMID: 28342741RCT
Time to transient and stable reductions in hot flush frequency in postmenopausal women using conjugated estrogens/bazedoxifene.
Pinkerton JoAnn V, Bushmakin Andrew G, Abraham Lucy et al. · Menopause · 2017
PMID: 28463874RCT
Longitudinal changes in menopausal symptoms comparing women randomized to low-dose oral conjugated estrogens or transdermal estradiol plus micronized progesterone versus placebo: the Kronos Early Estrogen Prevention Study.
Santoro Nanette, Allshouse Amanda, Neal-Perry Genevieve et al. · Menopause · 2017
PMID: 27779568RCTFull text (PMC)
The effect of conjugated estrogens/bazedoxifene therapy on body weight of postmenopausal women: pooled analysis of five randomized, placebo-controlled trials.
Black Denise, Messig Michael, Yu Ching-Ray et al. · Menopause · 2016
PMID: 26694733RCT

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Specialists

Providers who commonly manage this intervention

Endocrinology, Diabetes & Metabolism Physician

Internal Medicine — Endocrinology, Diabetes & Metabolism

NUCC 207RE0101X
Urology Physician

Urology

NUCC 208800000X
Find a Provider

Health Goals

Goals connected through associated conditions

Balance Hormones

Quick Facts

Type
Substance / Medication
Fully Specified Name
Conjugated estrogen (substance)
SNOMED CT
126098001
UMLS CUI
C0014938
RxNorm CUI
4099

Clinical Data

This intervention maps to 13 entities in the Healos knowledge graph.

7
Conditions
3
Biomarkers
2
Specialists
0
Symptoms
78
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.