Substance / Medication

Cortisone

SNOMED 32498003 UMLS C0010137

Overview

Active Ingredient

cortisone

RxNorm CUI

2878

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Complement C3c

LOINC 4485-9

primary

Eosinophils

LOINC 711-2

primary

IgE

LOINC 19113-0

primary

Nuclear Ab

LOINC 8061-4

primary

Clinical Trials

4 trials linked to this intervention

Total Trials

Recruiting

With Results

Recent Trials

Congenital Adrenal Hyperplasia Once Daily Hydrocortisone Treatment

NCT03760835Phase 4Recruiting150 enrolled

Theophylline and Steroids in Chronic Obstructive Pulmonary Disease (COPD) Study

NCT02261727Phase 4Completed1670 enrolled

Dual RElease Hydrocortisone Versus conventionAl Glucocorticoid replaceMent Therapy in Hypocortisolism (DREAM)

NCT02277587Phase 4Completed89 enrolled

Cortisone Injection vs Trigger Point Dry Needling Fin the Treatment of Greater Trochanter Pain Syndrome: A Pilot Study

NCT02639039Phase 4Completed50 enrolled

View all 4 trials on ClinicalTrials.gov

Research Evidence

Published studies and systematic reviews

Sort:

[Meta-analysis of hydrocortisone in the treatment of severe community-acquired pneumonia].

Gu Xue, Yang Penglei, Yu Lina et al. · Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · 2025

PMID: 40820529Meta-Analysis

Effect of hydrocortisone-fludrocortisone combination on mortality in septic shock: a systematic review and meta-analysis.

Wu Jheng-Yen, Liu Mei-Yuan, Liu Ting-Hui et al. · Infection · 2025

PMID: 39192056Meta-Analysis

Timing of hydrocortisone therapy in neonates with shock: a systematic review, meta-analysis, and clinical practice guideline.

Ramaswamy Viraraghavan Vadakkencherry, Kumar Gunjana, Pullattayil S Abdul Kareem et al. · Front Pediatr · 2025

PMID: 40144277Meta-AnalysisFull text (PMC)

Corticosteroids for sepsis and septic shock: a meta-analysis of 18 RCTs with dose-stratified and fludrocortisone subgroup evaluation.

Ruyuan Lv, Zhangshun Shen, Hongling Li et al. · BMC Anesthesiol · 2025

PMID: 41120996Meta-AnalysisFull text (PMC)

Effectiveness of Fludrocortisone Plus Hydrocortisone versus Hydrocortisone Alone in Septic Shock: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials.

Teja Bijan, Berube Megan, Pereira Tiago V et al. · Am J Respir Crit Care Med · 2024

PMID: 38271488Meta-AnalysisFull text (PMC)

Hydrocortisone in very preterm neonates for BPD prevention: meta-analysis and effect size modifiers.

De Luca Daniele, Ferraioli Sara, Watterberg Kristi L et al. · Arch Dis Child Fetal Neonatal Ed · 2024

PMID: 38237961Meta-Analysis

Early use of low-dose hydrocortisone can reduce in-hospital mortality in patients with septic shock: A systematic review and meta-analysis.

Song Binglin, Zheng Xiangde, Fu Kangrui et al. · Medicine (Baltimore) · 2024

PMID: 39612454Meta-AnalysisFull text (PMC)

Do We Need to Administer Fludrocortisone in Addition to Hydrocortisone in Adult Patients With Septic Shock? An Updated Systematic Review With Bayesian Network Meta-Analysis of Randomized Controlled Trials and an Observational Study With Target Trial Emulation.

Lai Pei-Chun, Lai Chao-Han, Lai Edward Chia-Cheng et al. · Crit Care Med · 2024

PMID: 38156911Meta-AnalysisFull text (PMC)

Efficacy and Safety of Hydrocortisone, Ascorbic Acid, and Thiamine Combination Therapy for the Management of Sepsis and Septic Shock: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.

Deng Jiawen, Zuo Qi Kang, Venugopal Kaden et al. · Int Arch Allergy Immunol · 2024

PMID: 38870923Meta-AnalysisFull text (PMC)

Effectiveness and safety of continuous subcutaneous hydrocortisone infusion in managing adrenocortical insufficiency in adult patients: a systematic review.

Alekrish Yazeed, Alotaibi Mohammed, Ekhzaimy Aishah · Rev Endocr Metab Disord · 2024

PMID: 39218827Meta-Analysis

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Specialists

Providers who commonly manage this intervention

Dermatology Physician

Dermatology

NUCC 207N00000X

Allergy & Immunology (Internal Medicine) Physician

Internal Medicine — Allergy & Immunology

NUCC 207RA0201X

Nephrology Physician

Internal Medicine — Nephrology

NUCC 207RN0300X

Rheumatology Physician

Internal Medicine — Rheumatology

NUCC 207RR0500X

Find a Provider

Health Goals

Goals connected through associated conditions

Manage Autoimmune Risk Promote Skin Health

Quick Facts

Type: Substance / Medication
Fully Specified Name: Cortisone (substance)
SNOMED CT: 32498003
UMLS CUI: C0010137
RxNorm CUI: 2878

Clinical Data

This intervention maps to 30 entities in the Healos knowledge graph.

Conditions

Biomarkers

Specialists

Symptoms

Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.