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Substance / Medication

Esterified estrogen

SNOMED 126099009 UMLS C0717752

Overview

Active Ingredient

estrogens, esterified (USP)

RxNorm CUI

214549

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Primary ovarian failure

Neoplasm of prostate

Neoplasm of breast

Menopausal flushing

Premature ovarian failure

Climacteric flushing

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

LOINC 3016-3

secondary

LOINC 2243-4

primary

LOINC 2986-8

primary

Clinical Trials

78 trials linked to this intervention

78

Total Trials

14

Recruiting

23

With Results

Recent Trials

TRADE-Testosterone Replacement and Dutasteride Effectiveness

NCT00194675Phase 4Completed53 enrolled

Study Evaluating Totelle® in Menopausal Symptoms and Sexual Function

NCT00195520Phase 4Completed100 enrolled

Efficacy and Safety Study in Postmenopausal Women to Determine the Lowest Effective Dose for Relief of Moderate to Severe Hot-Flushes

NCT00206622Phase 4Completed425 enrolled

Study of Paxil Use in Menopausal Women

NCT00225914Phase 4Completed64 enrolled

Estrogen for Treating Depression in Menopausal Women With Hot Flashes and Insomnia

NCT00227942Phase 4Completed86 enrolled

View all 78 trials on ClinicalTrials.gov

Research Evidence

Published studies and systematic reviews

Sort:

Women's experiences of premature ovarian insufficiency: a thematic synthesis.

Hammond Jennifer, Marczak Magda · Psychol Health · 2025

PMID: 36971566Meta-Analysis

Efficacy and Safety of Testosterone Replacement in Testicular Cancer Survivors With Treatment-Influenced Hypogonadism: A Systematic Review.

Fritz Andrew A, Reinert Justin P · Ann Pharmacother · 2025

PMID: 39250190Meta-Analysis

Intraovarian injection of autologous platelet-rich-plasma: myth or reality?

Loverro Giuseppe, DI Naro Edoardo, Loverro Matteo et al. · Minerva Obstet Gynecol · 2025

PMID: 39388219Meta-Analysis

Efficacy of Gonadotropin Treatment for Induction of Spermatogenesis in Men With Pathologic Gonadotropin Deficiency: A Meta-Analysis.

Muir Christopher A, Zhang Ting, Jayadev Veena et al. · Clin Endocrinol (Oxf) · 2025

PMID: 39445789Meta-Analysis

Safety and efficacy of low-dose esterified estrogens and methyltestosterone, alone or combined, for the treatment of hot flashes in menopausal women: a randomized, double-blind, placebo-controlled study.

Liu James, Allgood Adam, Derogatis Leonard R et al. · Fertil Steril · 2011

PMID: 20850731RCT

Effect of the combination of methyltestosterone and esterified estrogens compared with esterified estrogens alone on apolipoprotein CIII and other apolipoproteins in very low density, low density, and high density lipoproteins in surgically postmenopausal women.

Chiuve Stephanie E, Martin Lisa A, Campos Hannia et al. · J Clin Endocrinol Metab · 2004

PMID: 15126543Trial

Comparative effects of oral esterified estrogens with and without methyltestosterone on endocrine profiles and dimensions of sexual function in postmenopausal women with hypoactive sexual desire.

Lobo Rogerio A, Rosen Raymond C, Yang Hwa Ming et al. · Fertil Steril · 2003

PMID: 12798881Trial

Preliminary observations on differing psychological effects of conjugated and esterified estrogen treatments.

Friebely J S, Shifren J L, Schiff I et al. · J Womens Health Gend Based Med · 2001

PMID: 11268301Trial

Low-dosage esterified estrogens opposed by progestin at 6-month intervals.

Ettinger B, Pressman A, Van Gessel A · Obstet Gynecol · 2001

PMID: 11506834Trial

Low-dose esterified estrogens (0.3 mg/day): long-term and short-term effects on menopausal symptoms and quality of life in postmenopausal women.

Rebar R W, Trabal J, Mortola J · Climacteric · 2000

PMID: 11910619Trial

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Specialists

Providers who commonly manage this intervention

Endocrinology, Diabetes & Metabolism Physician

Internal Medicine — Endocrinology, Diabetes & Metabolism

NUCC 207RE0101X

Urology Physician

Urology

NUCC 208800000X

Find a Provider

Health Goals

Goals connected through associated conditions

Balance Hormones

Quick Facts

Type: Substance / Medication
Fully Specified Name: Esterified estrogen (substance)
SNOMED CT: 126099009
UMLS CUI: C0717752
RxNorm CUI: 214549

Clinical Data

This intervention maps to 13 entities in the Ltrl knowledge graph.

7

Conditions

3

Biomarkers

2

Specialists

0

Symptoms

78

Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.