Substance / Medication

Estradiol

Overview

Active Ingredient
estradiol
RxNorm CUI
4083

Indications

ESTRING is indicated for the treatment of moderate to severe symptoms of vulvar and vaginal atrophy due to menopause.

Labeler: Pfizer Laboratories Div Pfizer IncUpdated: 2026-02-26T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

ESTRING is contraindicated in women with any of the following conditions: 1 Abnormal genital bleeding with unknown etiology. 2 Known or suspected estrogen-dependent neoplasia. 3 Active DVT, PE, or a history of these conditions. 4 Active arterial thromboembolic disease (for example, stroke and MI), o

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Clinical Trials

78 trials linked to this intervention

78
Total Trials
14
Recruiting
23
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Estradiol Concentrations for Adequate Gender-Affirming Feminizing Therapy: A Systematic Review.
Winston-McPherson Gabrielle N, Thomas Tiffany A, Krasowski Matthew D et al. · LGBT Health · 2025
PMID: 40552461Meta-Analysis
Association between serum estradiol and cardiovascular health among transgender adults using gender-affirming estrogen therapy.
Rytz Chantal L, Miranda Keila Turino, Ronksley Paul E et al. · Am J Physiol Heart Circ Physiol · 2024
PMID: 38578239Meta-Analysis
Safety and Serum Estradiol Levels in Hormonal Treatments for Vulvovaginal Atrophy in Breast Cancer Survivors: A Systematic Review and Meta-Analysis.
Comini Ana Carolina M, Carvalho Bruno M, Moreira Matheus José Barbosa et al. · Clin Breast Cancer · 2023
PMID: 37806915Meta-Analysis

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Estradiol (substance)
SNOMED CT
126172005
UMLS CUI
C0014912
RxNorm CUI
4083
Labeler
Pfizer Laboratories Div Pfizer Inc

Clinical Data

This intervention maps to 13 entities in the Healos knowledge graph.

7
Conditions
3
Biomarkers
2
Specialists
0
Symptoms
78
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.