Substance / Medication

Phendimetrazine

Overview

Active Ingredient
phendimetrazine
RxNorm CUI
33272

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Clinical Trials

426 trials linked to this intervention

426
Total Trials
122
Recruiting
109
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Influence of phendimetrazine maintenance on the reinforcing, subjective, performance, and physiological effects of intranasal cocaine.
Stoops William W, Strickland Justin C, Alcorn Joseph L et al. · Psychopharmacology (Berl) · 2019
PMID: 30900008RCTFull text (PMC)
Central Retinal Vein Occlusion Noted 2 Days After Use of Phendimetrazine as an Appetite Suppressant.
Cho Ah Ran, Yoon Young Hee · JAMA Ophthalmol · 2016
PMID: 26846182Case Report
Transient environmental dependency syndrome due to phendimetrazine tartrate.
Hoffmann Michael · Eur Neurol · 2007
PMID: 17483586Case Report
Safety and tolerability of intranasal cocaine during phendimetrazine maintenance.
Stoops William W, Strickland Justin C, Hays Lon R et al. · Psychopharmacology (Berl) · 2016
PMID: 26932737OtherFull text (PMC)
Evaluation of the Reinforcing Strength of Phendimetrazine Using a Progressive-Ratio Schedule of Reinforcement in Rhesus Monkeys.
Minkiewicz Molly, Czoty Paul W, Blough Bruce E et al. · J Pharmacol Exp Ther · 2020
PMID: 32269168PreclinicalFull text (PMC)
Attenuation of cocaine self-administration by chronic oral phendimetrazine in rhesus monkeys.
Czoty P W, Blough B E, Fennell T R et al. · Neuroscience · 2016
PMID: 26964683PreclinicalFull text (PMC)
Dissociable effects of the prodrug phendimetrazine and its metabolite phenmetrazine at dopamine transporters.
Solis Ernesto, Suyama Julie A, Lazenka Matthew F et al. · Sci Rep · 2016
PMID: 27514281PreclinicalFull text (PMC)
Cocaine-like discriminative stimulus effects of phendimetrazine and phenmetrazine in rats.
Bauer Clayton T, Negus S Stevens, Blough Bruce E et al. · Behav Pharmacol · 2016
PMID: 26866973PreclinicalFull text (PMC)
Role of phenmetrazine as an active metabolite of phendimetrazine: evidence from studies of drug discrimination and pharmacokinetics in rhesus monkeys.
Banks Matthew L, Blough Bruce E, Fennell Timothy R et al. · Drug Alcohol Depend · 2013
PMID: 23211394PreclinicalFull text (PMC)
Effects of phendimetrazine treatment on cocaine vs food choice and extended-access cocaine consumption in rhesus monkeys.
Banks Matthew L, Blough Bruce E, Fennell Timothy R et al. · Neuropsychopharmacology · 2013
PMID: 23893022PreclinicalFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Phendimetrazine (substance)
SNOMED CT
373340007
UMLS CUI
C0070549
RxNorm CUI
33272

Clinical Data

This intervention maps to 9 entities in the Healos knowledge graph.

1
Conditions
3
Biomarkers
3
Specialists
0
Symptoms
426
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.