Back to Interventions

Substance / Medication

Phentermine

SNOMED 373343009 UMLS C0031447

Overview

Active Ingredient

phentermine

RxNorm CUI

8152

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

LOINC 2093-3

secondary

LOINC 4549-2

secondary

LOINC 2571-8

secondary

Clinical Trials

426 trials linked to this intervention

426

Total Trials

122

Recruiting

109

With Results

Recent Trials

Diabetes and Heart Disease Risk in Blacks

NCT00001853Recruiting2000 enrolled

Testosterone for HIV-Positive Men With Reduced Serum Testosterone Levels and Abdominal Fat

NCT00009555Phase 4Completed86 enrolled

Pediatric Hypothalamic Obesity

NCT00076362Phase 4Completed60 enrolled

The Safety and Effectiveness of Low and High Carbohydrate Diets

NCT00079547Phase 4Completed307 enrolled

Trial Comparing Metformin Versus Placebo in Non Alcoholic Steatohepatitis (NASH) Patients Receiving Bariatric Surgery for Obesity

NCT00134303Phase 4Completed65 enrolled

View all 426 trials on ClinicalTrials.gov

Research Evidence

Published studies and systematic reviews

Sort:

Efficacy and Safety of Phentermine/Topiramate in Adults with Overweight or Obesity: A Systematic Review and Meta-Analysis.

Lei Xiang-Guo, Ruan Jia-Qi, Lai Chen et al. · Obesity (Silver Spring) · 2021

PMID: 33864346Meta-Analysis

Phentermine: A Systematic Review for Plastic and Reconstructive Surgeons.

Lim Soobin, Rogers Lori K, Tessler Oren et al. · Ann Plast Surg · 2018

PMID: 30204622Meta-Analysis

Predictors of BMI reduction with phentermine/topiramate in adolescents with obesity.

Bensignor Megan O, Freese Rebecca L, Rudser Kyle D et al. · Int J Obes (Lond) · 2025

PMID: 40518455RCTFull text (PMC)

Comparison of mephentermine and norepinephrine infusions for prevention of post-spinal hypotension during elective caesarean delivery: a randomised, double-blind trial.

Mohta M, Kumari N, Chilkoti G T et al. · Int J Obstet Anesth · 2025

PMID: 39426031RCT

Evaluation of the efficacy and safety of controlled-release phentermine/topiramate in adults with obesity in Korea: A randomized, double-blind, placebo-controlled, phase 4 trial (QUEEN's study).

Hong Sangmo, Kim Won Jun, Kang Eun Seok et al. · Diabetes Obes Metab · 2025

PMID: 39703109RCTFull text (PMC)

Relative potency of norepinephrine and mephentermine bolus for the treatment of spinal hypotension during elective caesarean delivery: a randomized, blinded up-down sequential allocation study.

Mohta M, Kumar R, Salhotra R et al. · Int J Obstet Anesth · 2025

PMID: 40701126RCT

Effect of Phentermine on Hepatic Steatosis in Bariatric Surgery: A Pilot Study.

Pérez-Cruz Elizabeth, Guevara-Cruz Martha, Ortiz-Gutiérrez Salvador et al. · Med Princ Pract · 2022

PMID: 35526530RCTFull text (PMC)

Exenatide, Dapagliflozin, or Phentermine/Topiramate Differentially Affect Metabolic Profiles in Polycystic Ovary Syndrome.

Elkind-Hirsch Karen E, Chappell N, Seidemann Ericka et al. · J Clin Endocrinol Metab · 2021

PMID: 34097062RCT

A randomized, placebo-controlled crossover trial of phentermine-topiramate ER in patients with binge-eating disorder and bulimia nervosa.

Safer Debra L, Adler Sarah, Dalai Shebani Sethi et al. · Int J Eat Disord · 2020

PMID: 31721257RCT

Effects of liraglutide plus phentermine in adults with obesity following 1 year of treatment by liraglutide alone: A randomized placebo-controlled pilot trial.

Tronieri Jena Shaw, Wadden Thomas A, Walsh Olivia A et al. · Metabolism · 2019

PMID: 30902750RCTFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Specialists

Providers who commonly manage this intervention

Obesity Medicine (Family Medicine) Physician

Family Medicine — Obesity Medicine

NUCC 207QB0002X

Obesity Medicine (Internal Medicine) Physician

Internal Medicine — Obesity Medicine

NUCC 207RB0002X

Endocrinology, Diabetes & Metabolism Physician

Internal Medicine — Endocrinology, Diabetes & Metabolism

NUCC 207RE0101X

Find a Provider

Health Goals

Goals connected through associated conditions

Manage Weight and Body Composition Optimize Metabolic Function

Quick Facts

Type: Substance / Medication
Fully Specified Name: Phentermine (substance)
SNOMED CT: 373343009
UMLS CUI: C0031447
RxNorm CUI: 8152

Clinical Data

This intervention maps to 9 entities in the Healos knowledge graph.

1

Conditions

3

Biomarkers

3

Specialists

0

Symptoms

426

Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.