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Substance / Medication

Tibolone

SNOMED 395903002UMLS C0076660

Overview

Active Ingredient
tibolone
RxNorm CUI
38260

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Sleeplessness
Menopausal flushing
Climacteric flushing

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Cortisol

LOINC 2143-6

secondary

Thyrotropin

LOINC 3016-3

secondary

Clinical Trials

20 trials linked to this intervention

20
Total Trials
6
Recruiting
6
With Results

Recent Trials

Study Evaluating Totelle® in Menopausal Symptoms and Sexual Function

NCT00195520Phase 4Completed100 enrolled

Efficacy and Safety Study in Postmenopausal Women to Determine the Lowest Effective Dose for Relief of Moderate to Severe Hot-Flushes

NCT00206622Phase 4Completed425 enrolled

Study of Paxil Use in Menopausal Women

NCT00225914Phase 4Completed64 enrolled

Estrogen for Treating Depression in Menopausal Women With Hot Flashes and Insomnia

NCT00227942Phase 4Completed86 enrolled

Effect of Soy on Cognition and Hot Flashes in Men With Prostate Cancer Undergoing Testosterone Suppression Therapy

NCT00245518Phase 4Completed39 enrolled
View all 20 trials on ClinicalTrials.gov

Research Evidence

Published studies and systematic reviews

Sort:
The effect of Tibolone treatment on depression, anxiety and mood in women: a meta-analysis and systematic review of randomized controlled trials.
Dong Li, Wang Yi Gang, Zhang Ming et al. · Arch Womens Ment Health · 2025
PMID: 41123650Meta-Analysis
The effect of tibolone treatment on apolipoproteins and lipoprotein (a) concentrations in postmenopausal women: A meta-analysis of randomized controlled trials.
Li Cuiming, Wei Min, Mo Linling et al. · Eur J Obstet Gynecol Reprod Biol · 2024
PMID: 37948929Meta-Analysis
The effect of tibolone treatment on fasting blood sugar, insulin, insulin resistance and endothelial function in postmenopausal women: A meta-analysis of randomized controlled trials.
Zhu Yinghong, Zhu Yingbin, Chen Yan et al. · Exp Gerontol · 2021
PMID: 34627872Meta-Analysis
The effect of tibolone treatment on lipid profile in women: A systematic review and dose-response meta-analysis of randomized controlled trials.
Lv Changyu, Zhang Wencui, Tan Xia et al. · Pharmacol Res · 2021
PMID: 33865986Meta-Analysis
The effect of hormone replacement therapy and tibolone on lipoprotein (a) concentrations in postmenopausal women: A systematic review and meta-analysis.
Anagnostis Panagiotis, Galanis Petros, Chatzistergiou Vasileia et al. · Maturitas · 2017
PMID: 28364865Meta-Analysis
Effects of tibolone on fibrinogen and antithrombin III: A systematic review and meta-analysis of controlled trials.
Bała Małgorzata, Sahebkar Amirhossein, Ursoniu Sorin et al. · Pharmacol Res · 2017
PMID: 28760491Meta-Analysis
Short-term and long-term effects of tibolone in postmenopausal women.
Formoso Giulio, Perrone Enrica, Maltoni Susanna et al. · Cochrane Database Syst Rev · 2016
PMID: 27733017Meta-AnalysisFull text (PMC)
Tibolone decreases Lipoprotein(a) levels in postmenopausal women: A systematic review and meta-analysis of 12 studies with 1009 patients.
Kotani Kazuhiko, Sahebkar Amirhossein, Serban Corina et al. · Atherosclerosis · 2015
PMID: 26186655Meta-Analysis
Short and long term effects of tibolone in postmenopausal women.
Formoso Giulio, Perrone Enrica, Maltoni Susanna et al. · Cochrane Database Syst Rev · 2012
PMID: 22336846Meta-Analysis
Effects of tibolone or continuous combined oestradiol and norethisterone acetate on lipids, high-density lipoprotein subfractions and apolipoproteins in postmenopausal women in a two-year, randomized, double-blind, placebo-controlled trial.
Kotecha Payal Trupti, Godsland Ian F, Crook David et al. · Clin Endocrinol (Oxf) · 2020
PMID: 31925799RCT

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Specialists

Providers who commonly manage this intervention

Sleep Medicine (Internal Medicine) Physician

Internal Medicine — Sleep Medicine

NUCC 207RS0012X
Psychiatry Physician

Psychiatry & Neurology — Psychiatry

NUCC 2084P0800X
Sleep Medicine (Psychiatry & Neurology) Physician

Psychiatry & Neurology — Sleep Medicine

NUCC 2084S0012X
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Health Goals

Goals connected through associated conditions

Optimize Sleep Quality

Quick Facts

Type
Substance / Medication
Fully Specified Name
Tibolone (substance)
SNOMED CT
395903002
UMLS CUI
C0076660
RxNorm CUI
38260

Clinical Data

This intervention maps to 9 entities in the Healos knowledge graph.

3
Conditions
2
Biomarkers
3
Specialists
0
Symptoms
20
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.