Substance / Medication

Tryptophan

Overview

Active Ingredient
tryptophan
RxNorm CUI
10898

Indications

Aminosyn II, Sulfite-Free, (an amino acid injection) infused with dextrose by peripheral vein infusion is indicated as a source of nitrogen in the nutritional support of patients with adequate stores of body fat, in whom, for short periods of time, oral nutrition cannot be tolerated, is undesirable, or inadequate. SUPPLEMENTAL ELECTROLYTES, IN ACCORDANCE WITH THE PRESCRIPTION OF THE ATTENDING PHYSICIAN, MUST BE ADDED TO AMINOSYN II SOLUTIONS WITHOUT ELECTROLYTES. Aminosyn II can be administered

Labeler: ICU Medical Inc.Updated: 2025-11-02T00:00:00.000ZFull label on DailyMed

Boxed Warning

FDA Black Box Warning

Pharmacy Bulk Package – Not For Direct Infusion.

Contraindications

When this intervention should not be used

This preparation should not be used in patients with hepatic coma or metabolic disorders involving impaired nitrogen utilization.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Research Evidence

Published studies and systematic reviews

Sort:
The Tryptophan-Kynurenine pathway in people living with HIV: a systematic review.
Sebigi Tshiamo Will, Asia Levanco K, January Grant G et al. · Infection · 2025
PMID: 40448914Meta-AnalysisFull text (PMC)
Relationship Between the Gut Microbiome, Tryptophan-Derived Metabolites, and Osteoarthritis-Related Pain: A Systematic Review with Meta-Analysis.
Meléndez-Oliva Erika, Martínez-Pozas Oliver, Sinatti Pierluigi et al. · Nutrients · 2025
PMID: 39861394Meta-AnalysisFull text (PMC)
Biological function of d-tryptophan: a bibliometric analysis and review.
Wang Fei, Du Runyu, Shang Yunxiao · Front Microbiol · 2024
PMID: 39872820Meta-AnalysisFull text (PMC)
The role of tryptophan and its derivatives in musculoskeletal pains: A systematic review and meta-analysis.
De La Torre Canales Giancarlo, Al-Moraissi Essam Ahmed, Fatih Tina et al. · J Oral Rehabil · 2024
PMID: 38803211Meta-Analysis
The tryptophan catabolite or kynurenine pathway in long COVID disease: A systematic review and meta-analysis.
Almulla Abbas F, Thipakorn Yanin, Zhou Bo et al. · Neuroscience · 2024
PMID: 39424264Meta-Analysis
Tryptophan and Its Derived Metabolites as Biomarkers for Tuberculosis Disease: A Systematic Review
Maulina Novi, Hayati Zinatul, Hasballah Kartini et al. · Iran Biomed J · 2024
PMID: 39034495Meta-AnalysisFull text (PMC)
A systematic review and meta-analysis of the kynurenine pathway of tryptophan metabolism in rheumatic diseases.
Mangoni Arduino A, Zinellu Angelo · Front Immunol · 2023
PMID: 37936702Meta-AnalysisFull text (PMC)
Sex Differences in Tryptophan Metabolism: A Systematic Review Focused on Neuropsychiatric Disorders.
Pais Mariana Lapo, Martins João, Castelo-Branco Miguel et al. · Int J Mol Sci · 2023
PMID: 36983084Meta-AnalysisFull text (PMC)
The tryptophan catabolite or kynurenine pathway in autism spectrum disorder; a systematic review and meta-analysis.
Almulla Abbas F, Thipakorn Yanin, Tunvirachaisakul Chavit et al. · Autism Res · 2023
PMID: 37909397Meta-Analysis

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Tryptophan (substance)
SNOMED CT
54821000
UMLS CUI
C0041249
RxNorm CUI
10898
Labeler
ICU Medical Inc.

Clinical Data

This intervention maps to 7 entities in the Healos knowledge graph.

1
Conditions
2
Biomarkers
3
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.