celiac disease comprehensive panel

This panel detects three types of antibodies (IgA, IgG, and IgM) against Candida albicans, a yeast that normally lives on skin and in the digestive tract. Different antibody types indicate different stages of infection: IgM suggests recent or acute infection, IgG suggests past or chronic exposure, and IgA suggests mucosal exposure. Elevated levels may indicate candida overgrowth, yeast infections, or systemic candidiasis, particularly in immunocompromised individuals.

This test measures antibodies (IgA and IgG) against tissue transglutaminase (tTG), a protein involved in celiac disease. When people with celiac disease consume gluten, their immune system attacks this protein, producing these antibodies. Elevated levels are highly suggestive of celiac disease or dermatitis herpetiformis. This is the primary screening test for celiac disease and helps confirm diagnosis in those with symptoms like digestive issues, fatigue, or nutrient deficiencies.

IgA is an antibody (immunoglobulin) that plays a key role in immune defense, especially at mucous membranes like those in the gut and respiratory tract. IgA subclass 2 is one of two subtypes of IgA (the other being subclass 1). Low IgA subclass 2 levels can indicate immune system dysfunction or certain infections. This test is sometimes used to evaluate recurrent infections, gastrointestinal problems, or immunodeficiency disorders. IgA subclass deficiency may affect your ability to fight infections at mucosal surfaces, though the clinical significance can vary.

Tissue transglutaminase (tTG) antibodies are markers of celiac disease, an autoimmune disorder triggered by gluten consumption. When people with celiac disease eat gluten (found in wheat, barley, and rye), their immune system produces antibodies against tTG, damaging the small intestine. This antibody panel test typically includes IgA anti-tTG and/or IgG anti-tTG. A positive result suggests celiac disease and should be confirmed with intestinal biopsy. This test is essential for diagnosing celiac disease before it causes complications like nutritional deficiencies, osteoporosis, or increased cancer risk.

This test detects IgA antibodies to endomysium, the tissue surrounding muscle fibers. The endomysium IgA test is highly specific for celiac disease, an autoimmune condition triggered by gluten consumption. A positive result strongly suggests celiac disease, especially when combined with tissue transglutaminase (tTG-IgA) testing. This test is used for screening and diagnosis of celiac disease in patients with suspected gluten sensitivity. A positive result typically warrants follow-up with intestinal biopsy for confirmation.

This test detects IgG antibodies against Candida albicans, a common yeast organism. IgG antibodies indicate past or chronic exposure to Candida, not acute infection. Elevated levels may suggest chronic candidiasis, intestinal overgrowth, or systemic yeast infection, though interpretation is complex and controversial. In healthy people, IgG presence is normal due to environmental exposure. This test is sometimes ordered for suspected chronic yeast infections or immune dysfunction. However, a positive IgG result alone does not diagnose disease—clinical symptoms and additional testing are essential for diagnosis.

This test measures IgA antibodies against Candida albicans, a common fungus that normally inhabits your body. Elevated IgA levels suggest an immune response to Candida overgrowth or mucosal infection. IgA antibodies are particularly important at mucosal surfaces (mouth, gut, respiratory tract). Positive results may indicate oral thrush, vaginal yeast infections, or intestinal Candida overgrowth, helping identify fungal infections that require treatment.

This test measures IgM antibodies against Candida albicans, which are produced early in response to fungal infection. IgM antibodies indicate recent or acute infection, making this test useful for distinguishing new Candida infections from chronic or past exposures. Elevated IgM levels suggest your body is actively fighting a Candida infection, helping determine if antifungal treatment is needed and monitoring treatment response.

This test detects IgA antibodies against baker's yeast (Saccharomyces cerevisiae), which may indicate either an immune response to yeast or potential yeast sensitivity. Baker's yeast is common in bread and fermented foods. IgA antibodies are produced in mucosal tissues like the gut and suggest a localized immune response. Elevated levels may be associated with celiac disease, inflammatory bowel disease, or yeast sensitivity, though results require clinical correlation.

This test measures IgA antibodies against gliadin, a protein component of gluten. Your immune system produces these antibodies when exposed to gluten in people with celiac disease or gluten sensitivity. Elevated levels suggest an immune reaction to gluten in wheat, barley, and rye. This test helps diagnose celiac disease and monitor adherence to a gluten-free diet in diagnosed individuals.

Beta-2 glycoprotein 1 (β2GP1) IgA antibodies are immune proteins associated with antiphospholipid syndrome, an autoimmune condition that increases blood clotting risk. Elevated IgA antibodies to β2GP1 suggest immune activation against this protein. Positive results may indicate antiphospholipid syndrome, which increases risk of blood clots, miscarriage, and stroke. This test is typically performed alongside IgM and IgG testing for comprehensive evaluation.

This test detects antibodies (IgA and IgG) against gliadin and tissue transglutaminase, key markers for celiac disease screening. When people with celiac disease consume gluten, their immune system attacks intestinal tissue and produces these antibodies. A positive result strongly suggests celiac disease and warrants further testing with small intestinal biopsy for confirmation. Early detection is important because untreated celiac disease can cause intestinal damage, nutrient malabsorption, and long-term complications including osteoporosis and increased infection risk.