Treatments & Interventions
Research Evidence
Peer-reviewed studies linked via MeSH term "Anemia, Sickle Cell" from the MEDLINE/PubMed database.
Sort:
Impact of telehealth on hydroxyurea adherence and clinical outcomes in sickle cell disease management: A systematic review and meta-analysis.
[object Object], [object Object], [object Object] · J Manag Care Spec Pharm · 2026
Efficacy and Safety of Allogeneic Hematopoietic Stem Cell Transplantation in Curing Sickle Cell Disease: A Systematic Review and Meta-Analysis of Single-Arm Studies.
[object Object], [object Object], [object Object] et al. · Transplant Cell Ther · 2026
PMID: 40953733Meta-Analysis
Non-invasive prenatal testing for the diagnosis of sickle cell disease in high-risk pregnancies: A systematic review and statistical summary of the current literature.
[object Object], [object Object], [object Object] et al. · Eur J Obstet Gynecol Reprod Biol · 2026
PMID: 41192133Meta-Analysis
Palliative care needs of adults severely affected by sickle cell disease: A mixed-methods systematic review.
[object Object], [object Object], [object Object] et al. · Int J Nurs Stud · 2026
PMID: 41252804Meta-Analysis
CRISPR/Cas9 System as a Promising Therapy in Thalassemia and Sickle Cell Disease: A Systematic Review of Clinical Trials.
[object Object], [object Object], [object Object] et al. · Mol Biotechnol · 2026
PMID: 39794549Meta-Analysis
Blood-based protein biomarkers of sickle cell disease pain: a systematic review and meta-analysis.
[object Object], [object Object], [object Object] et al. · Pain · 2026
Global prevalence of elevated estimated pulmonary artery systolic pressure in clinically stable children and adults with sickle cell disease: A systematic review and meta-analysis.
[object Object], [object Object], [object Object] et al. · PLoS One · 2025
Priapism-related biomarkers in sickle cell disease: a systematic review.
[object Object], [object Object] · Sex Med Rev · 2025
PMID: 39916382Meta-Analysis
Factors Associated With Electrocardiographic Abnormalities in Patients With Sickle Cell Disease: A Systematic Review and Meta-Analysis.
[object Object], [object Object], [object Object] et al. · Pediatr Blood Cancer · 2025
PMID: 39950513Meta-Analysis
Impact of transcranial Doppler screening on stroke prevention in children and adolescents with sickle cell disease: A systematic review and meta-analysis.
[object Object], [object Object], [object Object] et al. · Blood Rev · 2025
PMID: 39710547Meta-Analysis
Search all PubMed articles for Sickle cell anemia
Research data from MEDLINE/PubMed
Signs & Symptoms
Based on Human Phenotype Ontology (HPO) disease-phenotype annotations.
Chronic hemolytic anaemia
Always present (100%)HP:0004870
Pain
Very frequent (80-99%)HP:0012531
Predisposition to infections
Very frequent (80-99%)HP:0002719
Abnormality of the spleen
Frequent (30-79%)HP:0001743
Bone infarction
Frequent (30-79%)HP:0010885
Bone infection
Frequent (30-79%)HP:0002754
Chest pain
Frequent (30-79%)HP:0100749
CKD
Frequent (30-79%)HP:0012622
Increased platelet count
Frequent (30-79%)HP:0001894
Increased total leukocyte count
Frequent (30-79%)HP:0001974
Iron-deficiency anaemia
Frequent (30-79%)HP:0001891
Osteoporosis
Frequent (30-79%)HP:0000939
Pigment gallstones
Frequent (30-79%)HP:0011981
Reticulocytosis
Frequent (30-79%)HP:0001923
Yellowing of the skin
Frequent (30-79%)HP:0000952
Abnormality of the nervous system
Occasional (5-29%)HP:0000707
Finger dactylitis
Occasional (5-29%)HP:0031090
Hyphema
Occasional (5-29%)HP:0011886
Hypoxia
Occasional (5-29%)HP:0012418
Impaired release of bile from liver
Occasional (5-29%)HP:0001406
Increased creatinine
Occasional (5-29%)HP:0003259
Increased lactate dehydrogenase level
Occasional (5-29%)HP:0025435
Ischemic stroke
Occasional (5-29%)HP:0002140
Open skin sore
Occasional (5-29%)HP:0200042
Persistence of haemoglobin F
Occasional (5-29%)HP:0011904
Priapism
Occasional (5-29%)HP:0200023
Primary pulmonary hypertension
Occasional (5-29%)HP:0002092
Retinal arterial occlusion
Occasional (5-29%)HP:0025326
Spleen infarct
Occasional (5-29%)HP:0034336
Unconjugated hyperbilirubinemia
Occasional (5-29%)HP:0008282
Related Conditions
Sickle cell anemia with high hemoglobin F(child)
Hemoglobin SS disease with crisis(child)
Hemoglobin SS disease without crisis(child)
Sickle cell anemia with coexistent alpha-thalassemia(child)
Sickle cell anaemia in mother complicating childbirth(child)
Anemia due to disturbance of hemoglobin synthesis(parent)
Anaemia due to intrinsic red cell abnormality(parent)
Sickling disorder due to hemoglobin S(parent)
Homozygous hemoglobinopathy(parent)
Quick Facts
- SNOMED CT
- 127040003
- UMLS CUI
- C0002895
- Fully Specified Name
- Sickle cell-hemoglobin SS disease (disorder)
- Specialists
- 0
- Diagnostic Biomarkers
- 0
- HPO Phenotypes
- 30
- Known Treatments
- 2
Medical Disclaimer
This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.
Clinical content is derived from the SNOMED CT clinical ontology and curated medical knowledge graphs.