Treatments & Interventions
Research Evidence
Peer-reviewed studies linked via MeSH term "Anemia, Sickle Cell" from the MEDLINE/PubMed database.
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Impact of telehealth on hydroxyurea adherence and clinical outcomes in sickle cell disease management: A systematic review and meta-analysis.
[object Object], [object Object], [object Object] · J Manag Care Spec Pharm · 2026
Efficacy and Safety of Allogeneic Hematopoietic Stem Cell Transplantation in Curing Sickle Cell Disease: A Systematic Review and Meta-Analysis of Single-Arm Studies.
[object Object], [object Object], [object Object] et al. · Transplant Cell Ther · 2026
PMID: 40953733Meta-Analysis
Non-invasive prenatal testing for the diagnosis of sickle cell disease in high-risk pregnancies: A systematic review and statistical summary of the current literature.
[object Object], [object Object], [object Object] et al. · Eur J Obstet Gynecol Reprod Biol · 2026
PMID: 41192133Meta-Analysis
Palliative care needs of adults severely affected by sickle cell disease: A mixed-methods systematic review.
[object Object], [object Object], [object Object] et al. · Int J Nurs Stud · 2026
PMID: 41252804Meta-Analysis
CRISPR/Cas9 System as a Promising Therapy in Thalassemia and Sickle Cell Disease: A Systematic Review of Clinical Trials.
[object Object], [object Object], [object Object] et al. · Mol Biotechnol · 2026
PMID: 39794549Meta-Analysis
Blood-based protein biomarkers of sickle cell disease pain: a systematic review and meta-analysis.
[object Object], [object Object], [object Object] et al. · Pain · 2026
Global prevalence of elevated estimated pulmonary artery systolic pressure in clinically stable children and adults with sickle cell disease: A systematic review and meta-analysis.
[object Object], [object Object], [object Object] et al. · PLoS One · 2025
Priapism-related biomarkers in sickle cell disease: a systematic review.
[object Object], [object Object] · Sex Med Rev · 2025
PMID: 39916382Meta-Analysis
Factors Associated With Electrocardiographic Abnormalities in Patients With Sickle Cell Disease: A Systematic Review and Meta-Analysis.
[object Object], [object Object], [object Object] et al. · Pediatr Blood Cancer · 2025
PMID: 39950513Meta-Analysis
Impact of transcranial Doppler screening on stroke prevention in children and adolescents with sickle cell disease: A systematic review and meta-analysis.
[object Object], [object Object], [object Object] et al. · Blood Rev · 2025
PMID: 39710547Meta-Analysis
Search all PubMed articles for Sickling disorder due to hemoglobin S
Research data from MEDLINE/PubMed
Signs & Symptoms
Based on Human Phenotype Ontology (HPO) disease-phenotype annotations.
Chronic hemolytic anaemia
Always present (100%)HP:0004870
Pain
Very frequent (80-99%)HP:0012531
Predisposition to infections
Very frequent (80-99%)HP:0002719
Abnormality of the spleen
Frequent (30-79%)HP:0001743
Bone infarction
Frequent (30-79%)HP:0010885
Chest discomfort
Frequent (30-79%)HP:0100749
Increased total leukocyte count
Frequent (30-79%)HP:0001974
Iron-deficiency anaemia
Frequent (30-79%)HP:0001891
Osteomyelitis
Frequent (30-79%)HP:0002754
Osteoporosis
Frequent (30-79%)HP:0000939
Pigment gallstones
Frequent (30-79%)HP:0011981
Progressive renal failure
Frequent (30-79%)HP:0012622
Reticulocytosis
Frequent (30-79%)HP:0001923
Thrombocythaemia
Frequent (30-79%)HP:0001894
Yellowing of the skin
Frequent (30-79%)HP:0000952
Brain and/or spinal cord issue
Occasional (5-29%)HP:0000707
Finger dactylitis
Occasional (5-29%)HP:0031090
Hyphema
Occasional (5-29%)HP:0011886
Hypoxia
Occasional (5-29%)HP:0012418
Impaired release of bile from liver
Occasional (5-29%)HP:0001406
Increased creatinine
Occasional (5-29%)HP:0003259
Increased lactate dehydrogenase level
Occasional (5-29%)HP:0025435
Ischemic stroke
Occasional (5-29%)HP:0002140
Open skin sore
Occasional (5-29%)HP:0200042
Persistence of haemoglobin F
Occasional (5-29%)HP:0011904
Priapism
Occasional (5-29%)HP:0200023
Primary pulmonary hypertension
Occasional (5-29%)HP:0002092
Retinal arterial occlusion
Occasional (5-29%)HP:0025326
Spleen infarct
Occasional (5-29%)HP:0034336
Unconjugated hyperbilirubinemia
Occasional (5-29%)HP:0008282
Related Conditions
Hemoglobin S sickling disorder with crisis(child)
Hemoglobin S sickling disorder without crisis(child)
Sickle cell anemia(child)
Double heterozygous sickling disorder(child)
Hemoglobin S-F disease(child)
Hereditary persistence of fetal hemoglobin with sickle cell disease syndrome(child)
Hereditary hemoglobin S(parent)
Quick Facts
- SNOMED CT
- 417357006
- UMLS CUI
- C0002895
- Fully Specified Name
- Sickling disorder due to hemoglobin S (disorder)
- Specialists
- 0
- Diagnostic Biomarkers
- 0
- HPO Phenotypes
- 30
- Known Treatments
- 2
Medical Disclaimer
This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.
Clinical content is derived from the SNOMED CT clinical ontology and curated medical knowledge graphs.