Substance / Medication

Sodium phenylbutyrate

Overview

Clinical overview including description, indications, and evidence base is pending physician authorship or FDA SPL integration. Graph-derived relationship data is available below.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

75 trials linked to this intervention

75
Total Trials
17
Recruiting
29
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Analysis of sodium phenylbutyrate and taurursodiol survival effect in ALS using external controls.
Paganoni Sabrina, Quintana Melanie, Sherman Alexander V et al. · Ann Clin Transl Neurol · 2023
PMID: 37807839RCTFull text (PMC)
Long-term survival of participants in the CENTAUR trial of sodium phenylbutyrate-taurursodiol in amyotrophic lateral sclerosis.
Paganoni Sabrina, Hendrix Suzanne, Dickson Samuel P et al. · Muscle Nerve · 2021
PMID: 33063909RCTFull text (PMC)
Impact of sodium phenylbutyrate treatment in acute management of maple syrup urine disease attacks: a single-center experience.
Zubarioglu Tanyel, Dede Elif, Cigdem Humeyra et al. · J Pediatr Endocrinol Metab · 2021
PMID: 33180043Trial
Trial of Sodium Phenylbutyrate-Taurursodiol for Amyotrophic Lateral Sclerosis.
Paganoni Sabrina, Macklin Eric A, Hendrix Suzanne et al. · N Engl J Med · 2020
PMID: 32877582TrialFull text (PMC)
A phase I dose-finding study of 5-azacytidine in combination with sodium phenylbutyrate in patients with refractory solid tumors.
Lin Jianqing, Gilbert Jill, Rudek Michelle A et al. · Clin Cancer Res · 2009
PMID: 19789320TrialFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Sodium phenylbutyrate (substance)
SNOMED CT
387058003
UMLS CUI
C0718066

Clinical Data

This intervention maps to 5 entities in the Ltrl knowledge graph.

5
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
75
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.